Vol 7, Issue 1
Pages 12–19
Published: 02 Feb 2023
DA Filkpièrè Léonard*, 1, 3, BALLO Mahamadou2, SOUDRE Albert1, TINDANO Basile3, BAH Sékou2, BAYALA Balé3
Article Information
Citation: DA Filkpièrè Léonard, BALLO Mahamadou, SOUDRE Albert, TINDANO Basile, BAH Sékou, BAYALA Balé. Effect of Sarcocephalus Latifolius B. Aqueous Extract Fruits on Gentamicin-Induced Nephrotoxicity in Rats. Journal of Pharmacy and Pharmacology Research 6 (2023): 12-19.
DOI: 10.26502/fjppr.066
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Abstract
Background and Aims: Inflammation is a reaction of the body whenever the integrity of its morphological and biological constants is threatened. All diseases affecting the great vital functions imply in their manifestation inflammation mediators. For the treatment, non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids are used. Although efficient, NSAIDs most often have side effects that hinder their long-term use. In Burkina Faso, medicinal plants combining anti-inflammatory and analgesic activities could be an alternative in anti-inflammatory therapy. The objective of the present study was to evaluate the effect of aquous extract of Sarcocephalus latifolius on gentamicin induced nephrotoxicity in experimental animal models.
Keywords
Nephrotoxicity, Gentamicin, Sarcocephalus latifolius, Electrolytes, Oxidative stress, Rat
Article Details
1. Introduction