Mesenteric Pseudocyst Following Blunt Abdominal Trauma: Report of a Case and Review of Literature

Klaudia Gjinoska^1*, Ognen Kostovski², Andrej Nikolovski³, Daniela Bajdevska Dukoska⁴, Agron Alimi⁵, Svetozar Antovic²

¹Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, North Macedonia

²University Clinic Digestive Surgery, Clinical Center "Mother Theresa", Skopje, North Macedonia; Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, North Macedonia

³University Clinic for Surgery "Sv. Naum Ohridski", Skopje, North Macedonia; Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, North Macedonia

⁴Institute of Pathology, Medical Faculty, University "St. Cyril and Methodius", Skopje, Republic of Macedonia; Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, North Macedonia

⁵General Hospital, Kumanovo, North Macedonia

^*Corresponding Author: Klaudia Gjinoska, Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, North Macedonia

Received: 29 September 2022; Accepted: 06 October 2022; Published: 12 October 2022

Introduction

Mesenteric pseudocysts are rare intraabdominal lesions. Trauma and infection have been discerned as possible causes, by means of hematoma or abscess resorption [1]. De Perrot’s histopathology classification of mesenteric cysts placed pseudocysts within a separate group, absence of epithelial lining being the common denominator. A total of 29 case reports were retrieved via the MedLine/PubMed search engine. The aim of this paper was to report a case of a mesenteric pseudocyst following blunt abdominal trauma and to review other previously published cases regarding this pathology.

Case Presentation

This is the case of a 27 year old female complaining of chronic abdominal pain for a few months prior to consult in the outpatient clinic. The aches were described as constant, dull, located in the mid abdominal region. Detailed interview brought to light an incident of blunt abdominal trauma that occurred 4-5 months earlier. Physical examination in the outpatient clinic was significant for abdominal tenderness in a wider area to the left of the umbilicus. Deep palpation did not reveal any abnormal growths. All lab values, including the serologic tumor markers fell within their reference ranges. The cystic lesion was first noted on ultrasound exam. Contrast enhanced computerized tomography (CT) scan and MRI were ordered for further characterization. The following traits were depicted by the cystic lesion on CT imaging: distinct margins, thin wall with subtle contrast enhancement, heterogeneous contents, and thick sediment. This round lesion measured 7cm x 6cm x 6,5cm and pushed away surrounding bowel (Figure 1a & 1b). MRI confirmed the CT diagnosis of a cystic fluid filled lesion, thick sediment, and mass-effect on adjacent bowel (Figure 2a,2b). The patient was scheduled for open surgery. Figure 3 presents the mesenteric pseudocyst enveloped by two peritoneal leaves of small bowel mesentery. The removed mesenteric pseudocyst is shown in figure 4. It was incompressible with slight elasticity upon pressure. Despite meticulous dissection, mesenteric vessel thrombosis led to segmental bowel ischemia, forcing segmental bowel resection. The postoperative period was uneventful. The patient was discharged on postoperative day 5. Pathological analysis revealed a unilocular cystic lesion filled with thick yellow-brown fluid with uneven inner surface. The following measurements were noted: weight 164g, size 7cm x 7cm x 5cm, wall thickness 3-4mm. Microscopic analysis was notable for the absence of epithelial lining, presence of collagen and smooth muscle fibers and chronic inflammation (See figure 5). The chronic inflammatory infiltrate consisted of the predominant lymphocyte population, the occasional lymphoid aggregate and foamy macrophages. The latter are scattered along the inner surface of the wall (Figure 6). Immunohistochemistry analysis yielded the following results: LCA+, CD68+, MCA -, CKAE1/AE3 -, CK7-, CD56-, CD10-.

Figure 1a: Contrast CT image of mesenteric pseudocyst axial plane

Figure 1b: Contrast CT image of mesenteric pseudocyst coronal plane

Figure 2a: Non-contrast MRI of mesenteric pseudocyst axial plane

Figure 2b: Non-contrast MRI of mesenteric pseudocyst coronal plane

Figure 3: The mesenteric pseudocyst on exploration

Figure 4: Removed specimen

Figure 5: Microphotograph of the pseudocyst wall lacking epithelium (H&E x 5)

Figure 6: Pseudocyst wall, immunohistochemistry CD68 positive histiocytes, 10x

Discussion

Mesenteric cyst is a term referring to all the cystic and pseudocystic lesions arising from the retroperitoneum, mesentery and omenta. Although some authors define mesenteric cysts as cyst arising exclusively from the bowel mesentery, we believe this practice to be inadequate for three reasons: 1. as dePerrot depicts, retroperitoneal, omental and mesenteric cysts derive from the same embryological structures 2. In many cases it is impossible to determine the exact anatomic origin of the cyst on preoperative imaging and intraoperative exploration [1]. 3. Scientific research would be simpler if all cystic and pseudocystic lesions arising independently from abdominal viscera are named mesenteric cysts.

Mesenteric cysts (retroperitoneal, mesenteric and omental) are rare lesions with an average incidence of 1/100 000 hospital admissions in adults [1]. The occurrence of mesenteric pseudocyst is quite rare, the number of published cases amounting to several dozen. Although rare, mesenteric cysts should be included in the differential for an abdominal cystic lesion detected by ultrasound or CT.

Mesenteric cysts are classified into six groups as follows: 1. cysts of lymphatic origin, 2. cysts of mesothelial origin, 3. cysts of enteric origin, 4. cysts of urogenital origin, 5. mature cystic teratoma, 6. nonpancreatic pseudocysts [1]. Traumatic and infectious pseudocysts are histogically similar to pancreatic pseudocyst which are usually surrounded by a thick fibrous wall without an inner epithelial lining [1].

Mesenteric cysts (including pseudocysts) may present as any other expanding intraabdominal lesion. Symptoms arise mainly from compression and displacement of adjacent structures, therefore, dull abdominal pain is the most common presenting symptom. Rarely, they present as a surgical emergency due to rupture of the cyst/pseudocyst or torsion of the mesentery.

There are several clinical scenarios at the time of diagnosis of mesenteric cysts. The most common scenario is intermittent abdominal pain and discomfort in one or more quadrants, with or without a palpable abdominal mass [2-6]. Another common scenario is the acute onset of intense abdominal pain in one quadrant, abdominal tenderness and sings of systemic inflammation (elevated heart rate, elevated body temperature, elevated CRP, leukocystosis, loss of appetite, nausea) [7-10]. An abdominal mass might or might not be palpable. Other clinical scenarios include midgut volvulus, partial or complete small bowel obstruction [11,12], hemiabdominal swelling and abdominal mass on palpation [13], disappearing and migrating abdominal mass [14]. Sometimes the mesenteric cyst is discovered as an incidental finding while diagnosing and treating for other conditions [15-17].

Primary retroperitoneal pseudocysts present in a slightly different fashion. Constant dull aching in one or two quadrants and/or palpable mass is the most common mode [18-24]. Possible additional symptoms include vomiting and a feeling of fullness. On single occasions the retroperitoneal pseudocyst has presented as bilateral reducible groin swellings [25], acute onset right lower quadrant pain increasing in severity with concomitant leukocytosis [26], has been discovered incidentally [27], and presented only as a palpable mass [28].

The majority of cases mesenteric pseudocyst either don’t report or specifically deny a history of abdominal trauma.  There are four cases reporting a history of blunt abdominal trauma, including a knee-kick, a traffic accident and a fall injury [3,4,12,29]. Therefore, lacking abdominal trauma history should not exclude the traumatic mesenteric cyst from the differential.

Traditionally ultrasound been considered as the primary modality for differentiating cystic and solid lesions and unilocular from multilocular lesions, CT offers the advantage of good spatial resolution, and MRI is best for tissue differentiation. MRI is not routinely obtained in the case of the mesenteric cystic lesion. In one case MRI determined the nonpancreatic origin of the cyst [3]. Magnetic resonance non-contrast series added little value to the investigative process in our case. It is unclear whether routine MRI use would increase preoperative diagnostic accuracy and aid in preoperative planning.

Pseudocysts display varying imaging characteristics, making correct preoperative diagnosis unlikely (see table). Distinct margins and compressing/displacing parenchymal organs and vascular structures are consistent features but common to all benign intraabdominal lesions. The mass-effect is only evident with larger lesions, but goes unnoticeable with lesions sized 5cm or less.

Total surgical excision of the nonpancreatic pseudocyst has been cited as the treatment of choice by all the authors. Total removal has been accomplished by enucleating using blunt and sharp dissection or by means of segmental bowel resection. Other options such as debridement, marsupialization, or partial excision have been considered inadequate due to concerns such as the possibility of malignant cell seeding, septic complications and risk of recurrence. These concerns arise generally as a consequence of diagnostic uncertainty. Benign cystic mesotheliomas and lymphangiomas have been shown to recur when incompletely resected [1]. However such occurrence hasn’t been demonstrated for the nonpancreatic pseudocyst. If diagnostic uncertainty weren’t an issue, attempts at treating the nonpancreatic pseudocyst as the pancreatic pseudocyst might yield satisfactory results, given their histopathological resemblance. Approaches other than total surgical excision might eliminate the necessity for extensive resection including adjacent bowel or parenchyma. 

Segmental bowel resection has been performed for the following reasons:  inability to exclude malignancy [6], avoiding rupture and spillage [6], intimate involvement of mesenteric vessels by the pseudocyst wall [4,14,15], proximity to bowel wall [10,15]. Wedge resection of the stomach [16] and removal of the left adrenal [22] have been performed for the same reasons.

Surgical removal has been achieved by means of open surgery, laparoscopy and the DaVinci robotic system. When faced with larger cystic lesions authors opted for the open approach [8,9,18,24]. The inability to exclude pancreatic or adrenal origin was the reason why the authors settle for the open approach [22]. The laparoscopic approach has been the most favored owing to the usual advantages of laparoscopy plus the high success rate in treatment of mesenteric cystic lesions [6,7,13,19,23,26,27,30]. Li et al. performed laparoscopic removal of a calcified pseudocyst through a retroperitoneal approach. Inadvertent puncture with content spillage occurred in two instances of laparoscopic removal. Calvar et al. decided for fluid aspiration through a Veress needle for safer removal. Chandradevan et al. discuss the potential advantages of a robot over open and laparoscopic removal, but also note that further data are needed to determine statistical significance.

Conservative management was attempted in one case and ceased due to symptom progression [9]. It is unknown to this date whether the watch and wait approach is feasible for the patient who remains symptom free.

Table 1: Combined radiologic characteristics from US and CT

Conclusions

Accurate preoperative characterization of mesenteric cystic lesions remains challenging. Presence of intraabdomial cystic lesion in a patient with positive history for abdominal trauma should raise the suspicion for a traumatic mesenteric pseudocyst. Total surgical excision of the nonpancreatic pseudocyst has been the treatment of choice. It remains unclear to this date whether other treatment approaches are feasible. Due to the rarity of mesenteric pseudocyst, designating a prospective study would include the effort and coordination of many surgical centers in the world. Because this is rather difficult, a more standardized style of reporting these cases would facilitate higher quality literature reviews in the future.

Acknowledgements

Funding not received

Conflicts of interest

None

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